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INFORMATION ABOUT GLUTATHIONE!!!

VANIDERM®

“The Most Economical 500mg Glutathione Preparation with 100mg Alpha Lipoic Acid and 100mg Vitamin C Proven Safe and Effective.”

BFAD Food Registration No: 58784

What is Glutathione?

• Small molecule that exist in high concentration throughout the body, most highly concentrated in the liver (at 10 millimoles and at least concentrated in the blood plasma 4.5 millimoles).
• Made up of 3 amino acids, L-cysteine, L-glutamic acid and L-glycine.
• Produced normally by the body in response today’s environment such as pollution it the air we breath, water we drink, chemicals & pesticides in the food we eat that cause damages in our cells & system.
• One the most very powerful water-soluble antioxidant agents known.
• It is so crucial to cellular health that is depletion within the cell leads to death of that cell.
• Natural choice for the prevention of age related diseases such as Alzheimer’s disease, arthritis and cataract .
• Has been studied as therapy for cancer, heart disease, support immunity against viral illness, slowing of natural aging process and more.

Common Name: GSH

Clinical Name: GLUTATHIONE

Synonym: Reduced L-Glutathione

Uses of Glutathione

A. MASTER ANTIOXIDANT (detoxifier) -

Substance that neutralizes harmful molecules called free radicals in the body.

• Major detoxification agent-binds to toxins such as heavy metals, solvents & transform them into a form that can be excreted in urine/bile.
• Essential for the functioning of the immune system.
• Major free scavenger enzyme protects individual cells and tissue of arteries, brain, heat, immune cells, and kidneys.
• Lens of eyes, liver, lungs, and skin against oxidant damage.
• Helps in preventing cancer especially liver cancer.
• Helps maintain the strength of RBC & protecting WBC.

Note: the recommended dose as antioxidant is 10mg per weight per day.

Classification of Antioxidants:

I. Endogenous Antioxidants (Cellular antioxidant-made in the body)

• Glutathione
• CoQ10
• Alpha Lipoic Acid

II. Antioxidant Phtytochemicals - photosynthetic nutrients/ plant: pigments.

• Carotenoids - best known as precursor of Vit. A

§ lycopene, lutein, zeaxanthin

§ fat soluble

§ found in colorful foods

• Bioflavonoids or Flavonoids - another type of plant pigment, found in fruits and vegs, also in red wine, beer, chocolate, coffee, algae and soy.

Major classes are:

• Flavonones
• Flavones
• Flavonols
• Isoflavones - soy, dong quai, black cohosh licorice and red clover
• Catechins - green tea
• Chalcones
• Anthocyanidins- grapeseed and pycnogenol

III. Herbal Antioxidants

- such as milk thistle, ginkgo biloba, curcumin and garlic.

IV. Antioxidant Vitamins

• Vitamin A
• Vitamin C
• Vitamin E

V. Antioxidants Minerals

• Selenium
• Zinc

VI. Antioxidant Hormone

• Melatonin

People who need VANIDERM®?

• Smokers
• Alcohol /caffeine drinkers
• 40 years old and above is a must
• who exercise excessively/body builders
• with low sperm account
• with liver problems
• with cataracts
• on chemotherapy recovery
• exposed to chemicals/pesticides
• with low immune system (recovery from sickness and operation)
• acetaminophen (paracetamol) frequent users

The following depletes Cellular Glutathione:

• acetaminophen (paracetamol)
• xenobiotics (hormone mimicking chemicals such as pills)
• aging
• air pollution
• UV radiations
• Smoking-increase the rate of utilization of glutathione
• alcohol
• caffeine
• vigorous exercise
• some other drugs

Health conditions associated with glutathione deficiency:

• Coordination problems
• Mental disorder
• Tremors
• Age related diseases
• Nervous system disorder
• Difficulty in balancing
• Lesions in the brain
• Diabetes mellitus
• Low sperm count
• Cataracts
• Cancer
• HIV infection

Note : Smokers ‘’people who smoke, are chronically exposed to toxins, suffer from conditions such as rheumatoid arthritis, diabetes mellitus, AIDS, cancer and has lower levels of glutathione.’’

It’s a vicious cycle: Health problems deplete the supply of glutathione & reduced levels of glutathione increase risk of health problems.

B. ANTI - AGEING

▪ Aids in the breakdown of oxidize fats.

▪ Glutathione is required for carbohydrate metabolism.

‘‘The greater exposure to toxins, the faster the body uses up its supply glutathione. Without the protection of Glutathione, cells die at a faster rate, making people age quicker and putting theme at risk for toxin induced diseases including cancer.’’

C. Researches on “WHITENS SKIN’’ as side effect?

▪ According to the studies glutathione in increased double dose posts a remarkable good ‘side effects’ such as SKIN WHITENING .

▪ By taking 20 - 40 mg per kg body weight (BW) in 3 divided doses per day.

Duration of gradual systematic skin whitening effect:

Medium brown skin : 1-3 months

Dark brown skin : 3-6 months

Very dark skin : 6-12 moths

Black skin : 2 years or more

Upon researching desired skin shades reduce the dose to 10 mg/Kg BW/day. Or maintenance dose of 1 capsule of Vaniderm® a day.

Note: According to clinical studies, Glutathione should be taken with other antioxidant such as Vitamin C, Vitamin E, Grape Seed Extract and Alpha Lipoic Acid. Glutathione regenerates oxidized Vitamin C and Vitamin E and vice versa while Alpha Lipoic Acid produces unending supply cysteine which boosts cellular production of GSH. Grape Seed extract plays a critical role in skin whitening if taken with GSH.

D. SLIMMING EFFECT

One of the building blocks of Vaniderm® is L-Cysteine which burns fat and produces learn muscles in high doses.

FREQUENTLY ASKED QUESTION (FAQ)

1. Why is Vaniderm® important to health?

▪ Protect cells by quenching some particularly dangerous free radicals (Including the hydroxyl radical)

▪ Its antioxidant power extends to protect DNA against oxidative modification

▪ It is the primary protectant of the eyes and skin against damaging ultraviolet (UV) radiation

▪ It is the foundation P450 detoxification system that neutralizes toxins in the liver, kidney, lungs and intestinal lining.

▪ Plays roles in the synthesis and repair of DNA, protein synthesis, amino acids transport in the synthesis of hormone life-prostaglandins.

▪ Plays an important role in the immune system enhancement.

2. Why is Vaniderm® with Vitamin C?

“A capsule of Vaniderm® contains 100mg of Vitamin C in order to regenerate glutathione (GSSG)”

Theodore Hersh. M.D

Emory University ,

School of Medicine , 2006

“Vitamin C is to keep glutathione in the reduced form so that they can continue to have their powerful free radical quenching effects”

3. Why is Vaniderm® with 100mg ALA?

What is the importance of Alpha Lipoic Acid (ALA)?

A capsule of Vaniderm® contains 100mg of Alpha Lipoic Acid (ALA) because the minimum Recommended Daily Allowance (RDA) is 100mg/day, but not to exceed Optimum dose of 600mg/day.

ALA (also known as the universal antioxidant) is one of the best supplement that boost intracellular glutathione levels other than its many health benefits.

“Recharges” vitamin C and E, as well as CoQ10.

Prevent formation of glycated proteins in test tubes studies, this explains why ALA is such a valuable supplement for diabetics. Free radicals are produced 50 times faster by glycated proteins than non glycated proteins. In Germany it is widely used to treat complications related to diabetes.

To help increase glutathione levels. “Lipoic acid is the only antioxidantthat can boost the level of intracellular glutathione, a cellular antioxidant of tremendous importance.”

- Life Extension Foundation 12/99

Also a chelator of heavy metals meaning that it helps move excessive amounts of metals such as a mercury, iron, aluminum and copper safely out of the body. These metals are known to enhance the production of free radicals.

4. What are free radicals?

Free radicals are atoms or group of atoms that can cause damage to cells, impairing the immune system and leading to infections and various degenerative diseases such as heart disease and cancer.

Most common among the known free radicals that occur in the body that is oxygen derived free radicals such as superioxide free radicals:

• Hydroxyl radicals
• Hydrogen peroxide
• Hypochlorite free radicals
• Various lipid peroxides
• Nitric oxide

They may be formed by:

• exposure to sun’s rays ( UV A, UV B, & UV C)
• exposure to radiation ( TV, PC, cell phones, microwave, x-rays)
• exposure to toxic chemicals
• cigarette smoke
• polluted air
• industrial
• household chemicals
• various metabolic processes

5. Are there any untoward side effects?

“No reported side effects or interactions are known with oral administration of glutathione has been reported so far even in prolonged use”

SKIN WHITENING is the better side effect/ secondary effect of GSH in “double increased dose, according to research.”

6. Are all Glutathione preparations in the market safe? NO

• Comes in 30 capsules

• Minimum of 3 bottles within metro manila free next day delivery