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| 71 :04x01 - Now You Know (Sep/30/2007) | | Wisteria is shocked after hearing the news about Edie. Meanwhile, Lynette undergoes chemotherapy and must cope with its side-effects and a new family moves into the neighborhood. | | Guest Stars: Nathan Fillion as Adam Mayfair, Kathryn Joosten as Karen McCluskey, John Slattery as Victor Lang, Polly Bergen as Stella Pollit, Pat Crawford Brown as Ida Greenberg, | Co-Guest Stars: Hailee Denham as Young Dylan, Coral Conroy as Young Julie, Zachary Gordon as Little Boy, Jim Klock as Security Guard, Gil Glasgow (1) as Man, Pamela Kosh as Mrs. McKeever, Coley Sohn as Nurse, Julia Campbell (1) as Muriel, Darien Pinkerton as Penny | Director: Larry Shaw Writer: Marc Cherry |
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| 72 :04x02 - Smiles of a Summer Night (Oct/07/2007) | | Lynette, stressed while battling cancer, kicks Tom out of her chemotherapy sessions. Meanwhile, Susan is mistaken for a stripper and Bree tries to steal a recipe. | | Guest Stars: Rachel Fox as Kayla, Pat Crawford Brown as Ida Greenberg, James Luca McBride as Al, Blake Hood as Boomer, Tahj Mowry as Matt, Kathryn Joosten as Karen McCluskey, Nathan Fillion as Adam Mayfair, | Co-Guest Stars: Matt Baker (1) as Teenage Boy #1 | Director: David Grossman Writer: Bob Daily (1), Matt Berry (1) |
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| 75 :04x05 - Art Isn't Easy (Oct/28/2007) | | Bob and Lee's water fountain sculpture in their front yard sparks a debate among Wisteria Lane residents. Meanwhile, Edie learns about Carlos and Gaby's affair just as John Rowland returns, hoping to rekindle his affair with Gabriel. | | Guest Stars: Eric Payne as Investigator, Austin Majors as Brett, Jonathan Kowalsky as Paramedic #1, Andrew Galves as Paramedic #2, Rachel Fox as Kayla, Pat Crawford Brown as Ida Greenberg, Michele Pierce as Tammy Rowland, Kevin Rahm as Lee McDermott, Tuc Watkins as Bob Hunter, Shirley Knight as Phyllis Van De Kamp, Kathryn Joosten as Karen McCluskey, Nathan Fillion as Adam Mayfair, Jesse Metcalfe as John Rowland | Director: David Grossman Writer: Jason Ganzel |
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| 76 :04x06 - Now I Know, Don’t Be Scared (Nov/04/2007) | | Edie's biggest fear is realized when Carlos walks out on her and their relationship. Susan finds Mike's father, a man who is supposedly dead, and everyone is shocked at a neighborhood Halloween party when an unexpected delivery arrives. | | Guest Stars: Norma Maldonado as Michelle, Soledad St. Hilaire as Helena, Kara Stribling as Eight-year-old Edie, George Wyner as Dr. Rushton, Kyle McCaffrey as Eight-year-old Boy, Patrick Bristow as Larry, Rachel Fox as Kayla, Gary Grossman as Irs Agent, Robert Forster as Nick Delfino, Nathan Fillion as Adam Mayfair, Kathryn Joosten as Karen McCluskey, John Slattery as Victor Lang, Polly Bergen as Stella Wingfield, Tuc Watkins as Bob Hunter, Kevin Rahm as Lee McDermott, Mike Farrell as Milton Lang | Director: Larry Shaw Writer: Susan Nirah Jaffee, Dahvi Waller |
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| 77 :04x07 - You Can't Judge a Book by Its Cover (Nov/11/2007) | | Victor questions Gaby about her affair with Carlos. Bree tells Susan that she suspects Mike is a drug addict. Meanwhile, a new Hodge moves into the neighborhood. | | Guest Stars: Pat Crawford Brown as Ida Greenberg, Greg Lewis as Stan, Julie Pop as Nurse, Tom Beyer as Dr. Hanson, Bob Glouberman as Mohel, Sarah Paulson as Lydia, Carrie Preston as Lucy, Polly Bergen as Stella Wingfield, John Slattery as Victor Lang | Director: David Warren Writer: Anne Flett-Giordano, Chuck Ranberg |
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| 78 :04x08 - A Distant Past (Nov/25/2007) | | Adam is shocked when a mysterious person from his past arrives on Wisteria Lane. Bree and Orson's marriage begins to suffer with a new baby in their lives. Meanwhile, Lynette reunites with her stepfather. | | Guest Stars: Billy Mayo as Detective Lyons, Coley Sohn as Nurse, Armie Hammer as Barrett, John O'Brien (1) as Dr. Wheeler, Melora Walters as Sylvia Greene, Patrick St. Esprit as Detective Berry, Soledad St. Hilaire as Helena, Sam Stefanski as Derek, Polly Bergen as Stella Wingfield, John Slattery as Victor Lang, Nathan Fillion as Adam Mayfair, Richard Chamberlain (1) as Glen | Director: Jay Torres Writer: Joe Keenan |
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| 79 :04x09 - Something's Coming (Dec/02/2007) | The residents of Wisteria Lane are forced into basements, cellars and safe rooms to weather a tornado that destroys homes and lives forever.
Source: ABC | | Guest Stars: Billy Unger as Chad, Christine Joaquin as nurse, Lynette DuPree (1) as Nurse #2, Eric Christie as orderly, Lee Oliver Boyd as female news anchor, Rachel Fox as Kayla, Bob Rusch as seurity guard, Eva Simone Fisher (1) as Mrs. Kowalsky, Barry Nolan as male news anchor, Nathan Fillion as Adam Mayfair, Kathryn Joosten as Karen McCluskey, John Slattery as Victor Lang, Pat Crawford Brown as Ida Greenberg, Melora Walters as Sylvia Greene, James Luca McBride as Al Kaminsky | Director: David Grossman Writer: John Pardee, Joey Murphy (1) |
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| 80 :04x10 - Welcome to Kanagawa (Jan/06/2008) | With Mrs. McCluskey's house completely destroyed, Lynette faces the possibility that her family and Ida Greenberg may not have survived; Katherine finds out that someone knows the truth about her mysterious past; and the residents of Wisteria Lane begin to rebuild their lives after the deadly tornado.
Source: ABC | | Guest Stars: Rachel Fox as Kayla, Eamon Hunt as Medical Examiner, Tom Titone as Doctor, Sergio Enrique as Police Officer, Adam Kulbersh as Carter, Meredith Scott Lynn as Erica, Sylva Kelegian as Diane, J. C. MacKenzie (1) as Walter Bierlich, Nathan Fillion as Adam Mayfair, Kathryn Joosten as Mrs. McCluskey, Tuc Watkins as Bob Hunter, Kevin Rahm as Lee McDermott, Mike Farrell as Milton Lang | Director: Larry Shaw Writer: Jamie Gorenberg, Jordan Nardino |
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| 81 :04x11 - Sunday (Apr/13/2008) | | While Kathryn has trouble keeping her deep secrets from the women onf Wisteria, Susan's attractive male cousin reveals more than Susan bargained for. Meanwhile, a surprise wedding takes place. | | Guest Stars: Rachel Fox as Kayla, Gary Cole as Wayne, Patricia Place as Nun, Mary K. Devault as Nurse Wilkins, Tom Titone as Dr. Dunlap, Jeff Doucette as Father Crowley, Dakin Matthews as Reverend Sikes, Chris Carmack as Tim, Kathryn Joosten as Karen McCluskey, Nathan Fillion as Adam Mayfair | Director: David Grossman Writer: Lori Kirkland Baker, Alexandra Cunningham (2) |
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| 82 :04x12 - In Buddy's Eyes (Apr/20/2008) | | Gaby struggles with the realization of having a blind husband while Lynette is shocked by the return of someone from her past. Meanwhile, Bree and Katherine pair up to plan the annual Founders' Day Ball. | | Guest Stars: Stephen Holland (1) as Caterer, Jodi Carlisle as Mrs. Downing, James Stellos as Photographer, Rachel Fox as Kayla, Charles Hutchins as Old Man, Patrick Robert Smith as Officer Daniels, Kent Faulcon as Officer Ramsey, Eddie McGee as Man In Wheelchair #2, Mitch Longley as Man In Wheelchair, Steven Lee Allen (1) as Customer, Jason Gedrick as Rick Coletti | Director: Larry Shaw Writer: Jeff Greenstein |
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| 84 :04x14 - Opening Doors (May/04/2008) | | Lynette learns the truth behind who started the fire at Rick's restaurant and is shocked by what she finds. Meanwhile, Bree gives Orson an ultimatum while Susan and Karl, her ex-husband, reconnect. | | Guest Stars: Rachel Fox as Kayla, Tatum Shank as Man, Amy Honey as Instructor, Tom Schmid as Dr. Oakley, Kathryn Joosten as Karen McCluskey, Kevin Rahm as Lee McDermott, Tuc Watkins as Bob Hunter, Sunny Mabrey as Marisa, Justine Bateman as Ellie Franks, Gary Cole as Wayne Davis, Richard Burgi as Karl Meyer | Director: David Grossman Writer: Dahvi Waller, Jordan Nardino |
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| 85 :04x15 - Mother Said (May/11/2008) | | Adele Delfino, Susan's mother-in-law, drops by Wisteria for a visit. Meanwhile, Carlos and Gaby learn their tenant, Ellie, has a deep secret. Later, a full-out war breaks out between Bree and Edie. | | Guest Stars: Rick Otto as Det. Paul Bullock, Amy Chaffee as Keri, Hailee Denham as Young Dylan, Rachel Fox as Kayla, Colleen McGrann as Lauren Baxter, Steve Kramer as Detective Hewitt, Peter Birkenhead as Dr. Joshua Dolan, Kathryn Joosten as Karen McCluskey, Gary Cole as Wayne Davis, Celia Weston as Adele Delfino, Justine Bateman as Ellie Franks | Director: David Warren Writer: Anne Flett-Giordano, Chuck Ranberg |
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| 86 :04x16 - The Gun Song (May/18/2008) | | The women of Wisteria join together to welcome Susan and Mike's new baby into the world. Meanwhile, Gaby strikes up a friendship with her tenant, Ellie; and Lynette is accused of child abuse. | | Guest Stars: Billy Gardell as Roy Harding, Kristen O'Meara as Griselda, Sonya Eddy as Vanessa, Melody Butiu as Nurse Janice, Michelle Marsh (1) as Sheila, Leslie Karpman (1) as Hostess, Danny Gurwin as Assistant Pastor, Helen Slayton-Hughes as Elderly Woman, Dale Waddington Horowitz as Nurse #1, Mark Brady as Cop #1, Rachel Fox as Kayla, Paul Keith as Joe, Wendy Schenker as Female Police Officer, Lisa Long as Irene Semanis, Nathan Fillion as Adam Mayfair, Gary Cole as Wayne Davis, Justine Bateman as Ellie Leonard, Tuc Watkins as Bob Hunter, Kevin Rahm as Lee McDermott, Peter Birkenhead as Dr. Dolan, Kathryn Joosten as Karen McCluskey, Rick Otto as Det. Paul Bullock, Bill Smitrovich as Rev. Green, Peggy Blow as Fern Parrish | Director: Bethany Rooney Writer: Matt Berry (1), Bob Daily (1) |
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| 87 :04x17 - Free (May/18/2008) | | The residents of Wisteria Lane are faced with deadly threats; Susan fears she may lose someone she loves; and Katherine Mayfair's dark secrets are revealed. | | Guest Stars: Sonya Eddy as Vanessa, Melody Butiu as Nurse Janice, Michelle Marsh (1) as Sheila, Paul Keith as Joe, Kristen O'Meara as Griselda, Leslie Karpman (1) as Hostess, Danny Gurwin as Assistant Pastor, Helen Slayton-Hughes as Elderly Woman, Dale Waddington Horowitz as Nurse #1, Mark Brady as Cop #1, Wendy Schenker as Female Police Officer, Lisa Long as Irene Semanis, Nathan Fillion as Adam Mayfair, Kathryn Joosten as Karen McCluskey, Gary Cole as Wayne Davis, Justine Bateman as Ellie Leonard, Tuc Watkins as Bob Hunter, Kevin Rahm as Lee McDermott, Peter Birkenhead as Dr. Dolan, Billy Gardell as Roy Harding, Rick Otto as Det. Paul Bullock, Peggy Blow as Fern Parrish, Gale Harold as Ken | Director: David Grossman Writer: Jeff Greenstein |
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